Avanços em Medicina

Uso de inibidores de bomba de prótons na indução ou agravamento do lúpus eritematoso: uma revisão sistemática de literatura

Micaella Yanne Fender Lobato — 2025-01-21

Introduction and objective: Drug-induced lupus erythematosus (LID) is a lupus-like syndrome temporally associated with continuous exposure to medications, many of which have not yet been effectively documented. Therefore, the objective of this study was to systematically search the scientific literature for primary articles related to the use of proton pump inhibitors in the induction of lupus or enhancement of pre-existing lupus and to verify whether the use of proton pump inhibitors induces or aggravates lupus erythematosus. Method: a systematic review was carried out, registered on the PROSPERO platform, searching the main databases (PubMed and VHL) between 1999 and 2022, with the keywords lupus and proton pump inhibitors, which followed the PRISMA recommendations. Results: Reports and case series were found that demonstrate an important association between the use of proton pump inhibitors and lupus, which presents in a heterogeneous form. Conclusion: Therefore, although it is not possible to identify a pattern, it is clear that there is an association between this medication used on a global scale and autoimmune disease.

Relationship between arterial hipertension in patients with diabetes mellitus in the southern and northeast regions of brasil : A literature review

Mayrla Barbosa da Silva — 2025-01-21

Introduction: Diabetes mellitus (DM) is a serious syndrome, with chronic symptoms and various complications, and difficult to control most of the time, currently being one of the biggest public health problems in our country. A study published by the Brazilian Society of Diabetes (SBD, 2019) points out that 50% of individuals diagnosed with DM did not even know they were diabetic. The incidence of these two diseases has increased in emerging countries due to changes related to wrong eating habits. Objective: The tendency of the relationship between arterial hypertension (AH) in patients with diabetes mellitus, in both diseases combined, was investigated, analyzing its association with factors that increase the risk of these diseases. Method: A literature review was carried out using the MEDLINE/PubMed, BIREME, Lilacs, SCIELO and Google Scholar databases, with articles published between 2013 and 2022. 24 manuscripts were selected to demonstrate the factors that most influenced this relationship between the diseases. Results: The articles revealed a worrying general panorama, with a significant increase in arterial hypertension and DM2 in the analyzed groups, and low adherence to eating habits that are known to be beneficial to health and, consequently, to the preventive treatment of these diseases in these regions. Conclusion: It was demonstrated that the relationship of arterial hypertension in patients with DM is an important risk factor in the population, in several Brazilian states, particularly in the South and Northeast regions. Thus, the study corroborates current preventive demands, relating the control of arterial hypertension in DM patients.

Melhorando Resultados Cirúrgicos: O Papel Vital do Suporte Contínuo dos Fornecedores de Material Cirúrgico

Bruno Campos de França — 2024-07-25

Enhancing surgical outcomes: the vital role of continuous support from surgical material suppliers

Bruno Campos de França — 2024-07-25